神經絲輕鏈蛋白 (Neurofilament light)是一種特別的細胞骨架蛋白，高度表現在大部分髓鞘化的軸突。腦脊液和血液中NfL的表現量上升對許多神經退行性疾病是臨床有用的生物標誌物，包括阿茲海默氏症(AD)，巴金森氏症(PD)，亨廷頓舞蹈症(HD)。^{1, 2}

“磁量”神經絲輕鏈蛋白品管液做為“磁量”神經絲輕鏈蛋白免疫磁減量檢測試劑(MF-NFL-0060)的品管材料。其檢測原理為當磁珠表面的神經絲輕鏈蛋白抗體與神經絲輕鏈蛋白結合後，磁珠會聚集成較大的分子，使磁珠在外加磁場下產生的磁減量 (χ_ac) 減少。而透過磁減量的變化量，可以簡單、精確地測得神經絲輕鏈蛋白的濃度。³

References

1. Lewczuk, P., Ermann, N., Andreasson, U., Schultheis, C., Podhorna, J., Spitzer, P., Maler, J. M., Kornhuber, J., Blennow, K., Zetterberg, H. (2018). Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer's disease. Alzheimer's research & therapy, 10(1), 71. doi:10.1186/s13195-018-0404-9
2. Hansson, O., Janelidze, S., Hall, S., Magdalinou, N., Lees, A. J., Andreasson, U., Norgren, N., Linder, J., Forsgren, L., Constantinescu, R., Zetterberg, H., Blennow, K., Swedish BioFINDER study (2017). Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder. Neurology, 88(10), 930-937. 
3. Che-Chuan Yang, Shieh-Yueh Yang, Jen-Jie Chieh, Herng-Er Horng, Chin-Yih Hong, Hong-Chang Yang, K. H. Chen, B. Y. Shih, Ta-Fu Chen, and Ming-Jang Chiu, “Biofunctionalized magnetic nanoparticles for specifically detecting biomarkers of Alzheimer’s disease in vitro”, ACS Chem. Neurosci. 2, 500 (2011).